Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6. In vitro studies have suggested these mutations affect several signaling pathways. but in vivo studies have largely compared wild-type and Trpc6-deficient rodents. https://www.jmannino.com/mega-choice-Rose-Gold-Herringbone-iPhone-13-Pro-MagSafe-Case-p93485-limited-save/