Background: Multiple Sclerosis (MS) is a neurodegenerative disease of central nervous system. Different approaches have been developed to study MS progression and cognitive dysfunction as the major symptom of the disease. The current study compared Optical Coherence Tomography (OCT) and Corpus Callosum Index (CCI) for the early evaluation of cognitive dysfunction in MS patients. https://www.roneverhart.com/Toshiba-AL13SX-AL13SXB30EN-300GB-15K-RPM-SAS-12Gb-s-512n-128MB-2-5-Hard-Drive/