In this paper. we proposed a contrast-enhanced homemade spectral domain optical coherence tomography (SD-OCT) method for monitoring of brain microcirculation. We used the polyethylene glycol (PEG)-ylated gold nanorods (GNRs) as a contrast-enhanced agent. obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels. https://www.parisnaturalfoodes.shop/product-category/green-tea/