BackgroundThe interplay between neoplastic cells and surrounding extracellular matrix (ECM) is one of the determinant elements for cancer growth. The remodeling of the ECM by cancer-associated fibroblasts (CAFs) shapes tumor microenvironment by depositing and digesting ECM proteins. hence promoting tumor growth and invasion. While for epithelial tumors CAFs are well characterized. https://icastorers.shop/product-category/books/